Obesity and Type 2 diabetes are serious chronic diseases associated with complex metabolic dysfunctions that increase the risk for morbidity and mortality
1- The dramatic rise in the prevalence of obesity and diabetes has become a major global public health issue and demands urgent attention.
2- Faced with the escalating global diabetes crisis, healthcare providers require as potent an armamentarium of therapeutic interventions as possible.
3- In addition to behavioural and medical approaches, various types of surgery on the gastrointestinal tract, originally developed to treat morbid obesity (‘bariatric surgery’), constitute powerful options to ameliorate diabetes in severely obese patients, often normalizing blood glucose levels, reducing or avoiding the need for medications and providing a potentially cost-effective approach to treating the disease.
* How is Metabolic / Bariatric Surgery defined:Alteration of the gastrointestinal tract that affects cellular and molecular signaling leading to a physiologic improvement in energy balance, nutrient utilization and metabolic disorders.
* Why consider bariatric surgery?
Both insulin resistance and insulin secretory reserve are important in the pathogenesis of Type 2 diabetes , but to different extents in different people. It is very important to recognize that not all Type 2 diabetes is the same and it is currently difficult to match the different therapies available to different phenotypes often resulting to suboptimal responses to therapy.
Type 2 diabetes is a progressive disease and the usual natural history is of progressive loss of insulin secretory capacity over time and the need for intensification of therapy and polypharmacy. Arresting this progression is a formidable therapeutic challenge. Treatment for Type 2 diabetes must also include active management of all cardiovascular risk factors (hypertension, dyslipidaemia, smoking and inactivity) but glycaemic control is very important—and not just for prevention of microvascular disease. Years of improved glycaemic control continue to deliver reduced risk of macrovascular disease and mortality over subsequent years.
* Bariatric surgery and Type 2 diabetes
Bariatric procedures aim to reduce weight and maintain weight loss through altering energy balance, primarily by reducing food intake and modifying the physiological changes that drive weight regain. There also appear to be independent metabolic benefits, associated with effects of incretins and possibly other hormonal or neural changes after some surgical procedures , in addition to weight loss. For example, rapid and sustained improvements in glycaemic control can be achieved within days of gastric bypass surgery, before any significant weight loss is eviden.